Nate and Sully exploring the jungle.
The Amazon Rainforest is a location that appears in Uncharted: Drake's Fortune. It appears in Chapter 2 - The Search for El Dorado and Chapter 3 - A Surprising Find.
Events in Uncharted: Drake's Fortune
Nathan Drake and Victor Sullivan traveled through the jungle in search for El Dorado. They discovered some hidden ruins, a U-Boat and unfortunately for them, Gabriel Roman, Atoq Navarro and their mercenaries.