A Bus is a vehicle that appears briefly in Uncharted 2: Among Thieves.
After Nate, Chloe and Sully have discovered where they should go to find the right temple. Nathan Drake travels to Nepal. When he arrives, a truck begins to follow him, causing the destruction of his Jeep. After that Nathan is trapped on a street full of guards, and some seconds later, a bus full of Resistance Fighters tried to kill those soldiers, but they fail, causing a crash into a wall, which destroys the bus and presumably kills the fighters.
After killing all the soldiers, if the player approaches the bus, it explodes, knocking Nate back a few metres, in which obligates the player to find another way around.