A bus is a vehicle that appears briefly in Uncharted 2: Among Thieves.
After Nathan Drake, Chloe Frazer and Victor Sullivan have discovered where they should go to find the right temple, Drake traveled to Nepal. When he arrived, a truck began tailing him, causing the destruction of his jeep. Following that, Nate was trapped on a street full of soldiers, and some seconds later, a bus full of Resistance Fighters tried to kill those soldiers, but they failed, causing a crash into a wall, which destroyed the bus and presumably killed the fighters.
After killing all the soldiers, if the player approaches the bus, it explodes, knocking Nate back a few meters, which obligates the player to find another way around.