The M4 is normally the first 'elite' weapon the player acquires in single-player campaign and is an upgrade over normal weapons.
Uncharted: Drake's Fortune (2007)
The M4 trades power for a heightened rate of fire and more accuracy than the AK-47. Not only does it remain accurate with prolonged fire, making it a great choice for long range combat, but it also slows down hit targets more so than the AK-47.
Uncharted 2: Among Thieves (2009)
Uncharted: Golden Abyss (2012)
Uncharted 4: A Thief's End (2016)
The M4 is only available in multiplayer. It was released alongside the Survival game mode update. The M4 can be dropped through DLC weapon chests or purchased for 400 Uncharted Points.
The M4 has medium recoil, medium accuracy, medium range, medium fire-rate, and low damage. It is best used at medium range.
In Uncharted and Uncharted 2, the M4 is seemingly modeled on the Colt Model 653, a carbine based on the M16 rifle. It's distinguished by the non-detachable carry handle, lack of a step in the barrel for mounting an M203, and lack of a brass deflector. In Uncharted 4, however, it is a correctly modeled M4 carbine.
As in Uncharted, the reload animation in Uncharted 2 is wrong—instead of pulling back the charging handle or hitting the bolt catch, Nate reloads it like an AK-47 by pulling back an invisible charging handle on the dust cover.