Talbot appears as a major character and the secondary antagonist of Uncharted 3: Drake's Deception, acting as a major foil to protagonist Nathan Drake. In addition, he also appears as a playable skin in the multiplayer modes of Drake's Deception and Uncharted 4: A Thief's End.
In all of his appearances, Talbot is voice acted and mo-capped by Robin Atkin Downes.
- "Little is known about the mysterious man known as Talbot, save for his allegiance to Katherine Marlowe and the secret order to which they belong. His dignified and regal bearing mask a sadistic streak, displayed through his liberal use of hallucinogens and hypnosis to get what he wants. Some speculate he has training as a magician; true or not, he's certainly capable of making people disappear."
- — Official Uncharted 4: A Thief's End bio.
Events of Uncharted 3: Drake's Deception
- "You're not really in a position to negotiate."
- — Talbot to Nate.
Talbot, Cutter, Nathan Drake and Victor Sullivan meet up in The Pelican Inn to supposedly trade the ring for money, when in reality, Nate and Sully are only trying to flush out Talbot and Katherine. Sully inspects the money and claims that it's counterfeit. Nate hastily takes back the ring and backs away, but Cutter and his thugs attack them.
While Nate and Sully fight Cutter and his thugs, Talbot flees from the Inn with the money. He meets Katherine and drives her car to Nate and Sully, who are trapped by Talbot's men in an alley. After Marlowe takes the ring, Nate attempts to grab it back, but Cutter shoots both him and Sully. Marlowe becomes furious at Cutter for his actions. Talbot is keen to get away, however, and drives off with Marlowe.
- "I held it in my hands - I saw him put it around his neck. This doesn't make sense..."
- — Talbot talking to Katherine about the ring.
Talbot and Marlowe then travel to their hidden library beneath London to decode the ring using Francis Drake's ring decoder.
However, the ring doesn't fit in the decoder, and they both realize that it's a fake. Marlowe orders her men to find Nate and bring the real ring back to her. Talbot and Marlowe then both leave the library, unaware of Nate's presence.
- "Empty those cans. Every last drop! Burn the whole place down."
- — Talbot ordering his men to burn the Chateau.
Inside the secret chamber beneath the Chateau, Talbot, Harris and another agent find Nate and Sully as they attempt to leave with one half of an amulet, an important clue to finding Iram. Talbot orders his right hand man called Harris to get the artifact, but when he does, a swarm of spiders crawl from the walls, and kill Harris. Talbot orders the other agent to acquire the amulet before it is long beneath the spiders. The agent succeeds, and the two of them leave the chamber. Later, Talbot orders his men to burn down the Chateau, in hope it will take care of Nate and Sully for good.
- "Don't trust Drake."
- — Talbot confusing Cutter.
Having had them followed too, Talbot travels to Syria to stop Chloe and Cutter from finding the other piece of the artifact, still under the impression Nate and Sully are dead. He discovers all four of them nearing the entrance, and decides to drug Cutter, forcing him to give his gun and journal to Talbot. Talbot disappears around a corner as Nate and the others arrive.
Talbot and his agents encounter Nate, Cutter, Chloe and Sully the next morning, after the heroes leave the crypt. Talbot orders the latter to drop their weapons and gloats about being equally matched until his other men arrive. Suddenly, Charlie acts as if he's been drugged again and points his gun at Nate. Talbot orders Cutter to shoot Nate after the heroes drop their guns, but Cutter was merely pretending and shoots Talbot in the chest. The four escape to a nearby tower in hopes of losing Talbot and the agents.After Cutter is left trapped on the tower mere minutes later, Talbot arrives with Marlowe. To Cutter's confusion and horror, he shows no ill effects from the gunshot. He takes the amulet from the reluctant Cutter before Marlowe's agents pour gasoline around him. She then lights a flame, leaving Cutter trapped. Talbot and Marlowe then disperse, leaving their agents to take care of Nate and the others.
- "Sully's not here, Drake."
- — Talbot drugging Nate.
With the amulet solved, Talbot arrives in Yemen the same time Nate is there. Unknown to Nate, Talbot is fully aware that Nate is following him through the streets. After Nate rounds the corner in a hotel, Talbot hits him with a brutal punch, before throwing Nate out of the window.
Talbot appears again when he drugs Nate, using the same method he used on Charlie Cutter. Nate has hallucinations while hearing Talbot telling him to relax. The hallucination ends, and Nate finds himself in a Yemen square with Katherine Marlowe, Talbot and Rameses. Talbot keeps silent throughout the conversation between Marlowe and Nate, until he informs Katherine that Sully, who knows the coordinates to find Iram of the Pillars, has been discovered. Nate loses his temper, throws the table forward, and chases after Talbot. Eventually the two of them both arrive at a rooftop with no easy escape. The two have a quick fist fight, before Rameses knocks Nate out with a large wooden board.
- "You can't just let her die!"
- — Talbot pressing Nate to save Katherine
After arriving in Iram, Talbot kills Sully with a T-Bolt Sniper after an eclipse. Enraged, Drake chases Talbot, following him down an elevator shaft. Talbot drops a smoke bomb behind him, blinding Nate at first, before forcing him into another level of hallucination.
Nate gives chase to Talbot, but loses him, and is instead confronted by a number of odd hallucinations which is caused by the water.
Talbot and Marlowe made their way towards the center of the city, discovering a small reservoir, containing a brass jar that Marlowe is seeking. They used a crane to lift the brass vessel out but Nate and Sully arrived to thwart their plan by destroying the winch, creating a destructive chain reaction that ends up causing the entire city (which apparently resided atop a dormant sinkhole of quicksand) to collapse. Talbot grabbed Katherine and the two of them dispersed.
Talbot and Marlowe ran into Nate and Sully later on a spiral staircase, as the city falls apart. The staircase collapsed, and Talbot, Marlowe, and Nate became trapped in a pit of quicksand. After Talbot and Nate are able to get out of the quicksand, Talbot yelled at Nate to save Marlowe. Nate tried to rescue Katherine but she was already in too deep and was sucked beneath the sand, suffocated. Nate and Sully dispersed as Talbot cried in despair.
Nate and Sully almost reach the exit, but Talbot, having inconspicuously found another way to the surface beforehand, suddenly blocked Nate's way. Talbot pulled out a knife and engaged in a brutal fist fight with Nate, attempting to stab him but Nate overpowered him at every turn. Eventually, Talbot managed to gain the upper hand, and would have killed Nate, if not for Sully's intervention. Sully came to Nate's rescue by shooting Talbot in the shoulder with a pistol, but the platform crumbled and Nate fell off while Sully lost his pistol. Nate managed to recover it while grasping the side of the platform. Talbot, fought Sully, and, beating him, was about to crush his head with a rock. Nate shot and killed him, and his body fell off the platform, into the sinking city.
Talbot appears in his mid-30s just like Drake. He has black hair and gray eyes. He is always dressed in a suit with a red tie, slacks, and dress shoes. During chapter 11, he removes the jacket and loosens his tie. In the last chapter, he tucks his sleeves and doesn't have his tie.
Naughty Dog states in the Official Game Guide that they specifically created Talbot to be a foil of Drake: 'he's a man of roughly the same age and physical ability as Drake', Naughty Dog calling him the 'anti-Drake'. He has slicked hair, and a rather pointy chin, but the developers tried to imagine parts of Drake in his final appearance. Everything was intended to make him a 'worthy match for Drake'. His entire character was built around this.
Talbot is somewhat sadistic, and violent when aggravated. He also seems deeply attached to Marlowe as he expresses deep rage when Drake fails to rescue her. He also will manipulate others to do things for him such as when he drugged Cutter to give him his notebook. He also shows intelligence, because when he was fleeing from Drake, he knew if he attempted to fight in the open, both of them would have been captured by the Yemen Police Force.
- Chapter 1 - Another Round
- Chapter 5 - London Underground
- Chapter 6 - The Chateau
- Chapter 7 - Stay in the Light
- Chapter 8 - The Citadel
- Chapter 9 - The Middle Way
- Chapter 10 - Historical Research
- Chapter 11 - As Above, So Below
- Chapter 21 - The Atlantis of the Sands (Hallucination)
- Chapter 22 - The Dreamers of the Day
- It is unknown what his full name is and whether Talbot is a first name or a surname.
- The surname Talbot is of French origin meaning "reward." 
- As a given name, there are conflicting sources concerning its etymology.
- Talbot's name might be based off an
from the 1900s.
- It is also possible that Talbot's name is based on the infamous 16th century alchemist, Edward Talbot (also known as Edward Kelly) who accompanied John Dee as his accomplice for most of Dee's life as an alchemist.
- Robin Atkin Downes also provided the voice of Atoq Navarro in Uncharted: Drake's Fortune, as well as the voices of some of Lazarevic's Soldiers and Tenzin's motion capture in Uncharted 2: Among Thieves. This marks the second time Robin Atkin Downes has played the role of a villain in the Uncharted series.
- Rafe, Talbot and Navarro are the only three villains in the main series to be killed by Nathan Drake (he also kills Roberto Guerro in Golden Abyss).
- Drake is indirectly responsible for Marlowe's death since he caused the city to collapse, which in turn caused her to fall into the quicksand.
- He is nicknamed Magic Man by Drake during the Yemen boss fight; while they are fist fighting, it is possible to hear Drake tauntingly say "Come on, Magic Man." This is a clear reference to his abilities as an illusionist.
- In Cutter's notebook (and via gameplay mechanics, Drake's journal), two specific tarot cards are pictured: "The Magician" and "The High Priestess", with Talbot's name written above the former and Marlowe's name written under the latter. In mysticism, the Magician is said to be able to make anything he imagines real simply by saying it aloud, referencing Talbot's control of Cutter. The tarot card he slips Cutter is "The Tower", a card traditionally referring to a great fall or a rude awakening. This is a clear reference to his subsequent forced jump from the high tower he was standing on after being confronted by Talbot and Marlowe, who proceeded to burn the platform after their men poured gasoline all around Cutter.
- Talbot, Nate, Sully, Salim, Eddy, Rameses, Cutter, and Lazarević are the only characters to have Doughnut character skins.
- In multiplayer, his vocal grunts when he jumps or climbs are similar to Lazarević's soldiers. Robin Atkin Downes also voiced the soldiers from Uncharted 2. In addition, many of Talbot's death vocals are borrowed from Atoq Navarro.
- Talbot's use of fifty pound notes to pay Nate seems designed to show him underestimating the American's intelligence; until the 2nd of November 2011 the £50 note had never been redesigned with modern security features, and £50 notes are so likely to be fake that most stores will not accept them.
- He looks older and paler in the E3 trailer than in the final game.
- It is never openly explained how Talbot disappeared in Syria or how he was able to survive being shot by Cutter. Amy Hennig stated that Talbot is an illusionist and that he could have used a bulletproof vest for the gunshot from Cutter and an escape wire for his disappearance. Sully and Drake also fake their own deaths through Cutter with the use of bulletproof vests and blood packs. Cutter remarks after jumping from the tower that he shot Talbot in his waist coat, so it is very likely that if he were wearing some sort of body armor it would have protected him. The caliber of the round and shock of impact would be enough to knock him down as seen without actually killing him, making it plausible for him to appear perfectly composed again in the next cutscene. Ultimately, these plot points help to drive the narrative of mystique and occult characteristics of the main antagonists, as well as Talbot's tarot depiction as the magician.
- Talbot and Desert Talbot multiplayer skins have different phrases, unlike other characters with different skin variants.
- Talbot is the only principal antagonist to be killed during the actual gameplay.