Tenzin has a daughter named Pema. In Uncharted 2: Among Thieves, Tenzin rescued a gravely injured Nathan Drake from train wreckage in the Himalayas before bringing him to his home in a small Tibetan village. He kept the unconscious Drake in his home for a few days, until he awoke and recovered from his injuries. He and Drake are sent by Karl Schafer to search for his expedition in the Himalayan ice caves. While in the ice caves, Tenzin saves Nathan from a suited guardian by stabbing it with his kukri. After their encounter with the guardian, the two discover an ancient ice temple hidden in the caves. Drake and Tenzin solve numerous puzzles to reach the inner sanctum of the temple, where they discover the remains of the expedition. The two are attacked by more Guardians, but narrowly escape in an ancient lift.
After escaping the temple, Tenzin and Nate find that the village under attack by mercenaries led by Zoran Lazarevic. The two battle through the village and take down a tank that destroys Tenzin's home. Once Tenzin is reunited with his daughter, Nate and Elena go after Schafer, and Drake bids his goodbye to Tenzin.
After Nate, Elena, and Chloe return from their journey to destroy the Cintamani Stone, Tenzin hosts a Tibetan funeral for Schafer.
Tenzin is available as a default multiplayer skin in the "Heroes" side.
Even with subtitles turned on, players are not told what Tenzin is saying. Instead they are just told that he is 'speaking Tibetan'.
Tenzin appears to be very strong and resilient, as evidenced by his getting pounded by a Guardian during the expedition through the mountains, whereas Zoran, who was much bigger and stronger was killed in a similar way. An explanation of this is that the Guardians beat Zoran constantly while Tenzin's encounter lasted only for a couple of seconds. Also, Tenzin was attacked by one Guardian, while at least half a dozen attacked Zoran.
His Kukri is only seen being used once and cannot be used by the player.
Similar to Talbot, it is unknown whether Tenzin is his last or first name.
Nate appears to trust Tenzin, even though the two never seem to have a conversation that the other understands.