Uncharted 2: Among Thieves
When Drake and Tenzin are exploring the ice caves, a pack of wolves appear above them. While Drake seems worried, Tenzin is calm. Later on they find a pack of dead wolves that died of unknown causes. Later on the game Drake and Tenzin encounter a yeti and it is implied that that killed the wolves.
Near the white wolf (as seen in the picture above) is a perfect paw print in the blood. This is identical to the paw symbol used in the Naughty Dog logo.